Endocannabinoid System

What is it!

Discovered in the 20th Century, the endocannabinoid system is a biological system composed of endocannabinoids that are neurotransmitters that bind to cannabinoid receptors in the mammalian brain and body. CBD is one of the primary cannabinoids found in hemp.

These cannabinoid receptors play a pivotal role in physiological processes such as mood, memory and pain. There are two cannabinoid receptors – CB1 and CB2 that are located on cells throughout the body.

What are CB1 and CB2 receptors?

CB1 receptors are primarily located on nerve cells in the brain, spinal cord and central nervous system. They are very abundant in the cerebellum, basal ganglia, and hippocampus. The CB1 receptors have been found to play a role in memory processing, motor regulation, pain sensation, mood, and sleep. CB2 receptors are primarily found on cells in the immune system and its associated structures. When activated, they stimulate a response that fights inflammation, which can reduce pain and minimize damage to tissues.

CBD Receptors

Concentrations

Cannabinoid Receptor 1 (CB1)

1 - BRAIN / CNS / SPINAL CORD CORTIGAL REGIONS / CEREBELLUM / BRAINSTREAM

(neocortex, pyiform cortex, hippocampus, amygdala)

2 - THYROID

endocrine gland

3 - UPPER AIRWAYS

of mammals

4 - LIVER

kuppfer cells (macrophage immune cells), hepatocytes (liver cell), hepatic stellate cells (fat storage cell)

5 - ADRENALS / BASAL GANGLIA / THALAMUS / PITUITARY / HYPOTHALAMUS / OLFACTORY BULB

endocrine gland / Globus pallidus, substantia nigra pars, reticula / (endocrine-brain link CBD1)

6 - OVARIES

gonads and endocrines gland

7 - UTERUS

myometrium

8 - PROSTATE

epithelial and smooth muscle cells

9 - TESTES

gonads and endocrines gland CB1: Leyding cells; sperm cells

Cannabinoid Receptor 2 (CB2)

1 - EYE

Retinal pugment epithelial/RPE cells

2 - STOMACH
3 - HEART
4 - PANCREAS
5 - DIGESTIVE TRACT
6 - BONE

Brain

1 - BASAL GANGLIA

Movement

2 - CEREBRAL CORTEX

Higher Cognitive Fucntion

3 - HYPOTHALAMUS

Appetite

4 - CEREBELLUM

Movement

5 - HIPPOCAMPUS

Learning, Memory, Stress

6 - MEDULLA

Nausea and vomiting, chemoreceptor

7 - SPINAL CORD

Peripheral Sensation including Pain

How do these

Receptors work?

Cannabinoids help coordinate and regulate how we feel and think by binding with the endocannabinoid system’s CB1 and CB2 receptors. Fitting like puzzle pieces, cannabinoids are designed to link together with the cannabinoid receptors.

Linking activates the receiving neuron into action, triggering a set of events to pass along the message and carry out a variety of cellular responses needed for homeostasis and healthy functioning.

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